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RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

  • ISSN (Print) 0044-460X
  • ISSN (Online) 3034-5596

Synthesis and study of some properties of new tetrazole-containing derivatives of morpholin-4-yl-1,3,5-triazine and 4-methylpiperidin-1-yl-1,3,5-triazine

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PII
10.31857/S0044460X23050050-1
DOI
10.31857/S0044460X23050050
Publication type
Article
Status
Published
Authors
O. V Mykolaichuk
  • Affiliation:
    I.P. Pavlov First St. Petersburg State Medical University
    Academician A. M. Granov Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
M. V. Kozlova
  • Affiliation:
    I.P. Pavlov First St. Petersburg State Medical University
    Academician A. M. Granov Russian Research Center for Radiology and Surgical Technologies, Ministry of Health of the Russian Federation
    St. Petersburg State Institute of Technology (Technical Univer
Volume/ Edition
Volume 93 / Issue number 5
Pages
695-710
Abstract
New tetrazole-containing derivatives of morpholin-4-yl-1,3,5-triazine and 4-methylpiperidin-1-yl-1,3,5-triazine were synthesized. Cytotoxic activity of the compounds obtained against human liver tumor cell lines Huh-7 and human lung A549 was studied by the MTT test. It was shown that these substances do not exhibit a pronounced cytotoxic effect. The most significant antitumor activity was shown by 1,3,5-triazine containing 5-phenyltetrazol-2-ylacetohydrazide fragment and 4-methylpiperidine ring as substituents, as well as 1,3,5-triazine containing 5-methyl-1 H -tetrazol-1-ylacetohydrazide fragment and two morpholine rings. For these compounds, the interaction with DNA was studied by UV spectroscopy. For N ’-(4,6-dimorpholino-1,3,5-triazin-2-yl)-2-(5-methyl-1 H -tetrazol-1-yl)acetohydrazide, the DNA binding constant was determined ( K bin 9.02× 104 M.-1) and studied the ability to inhibit the tyrosine kinase domain of surface receptors. It was shown that the studied tetrazole-containing derivatives of 1,3,5-triazine do not exhibit antioxidant properties with respect to NO-radicals and do not cause photoinduced hemolysis.
Keywords
1,3,5-триазин 5-арилтетразолы 5-метил-1H-тетразол-1-илацетогидразид 5-фенил-2H-тетразол-2-илацетогидразид цитотоксическая активность ингибирующая активность
Date of publication
17.09.2025
Year of publication
2025
Number of purchasers
0
Views
13

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