Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones

Podchezertseva, K.V.; Buzmakova, N. A.; Zamaraeva, T. M.; Zykova, S. S.; Dmitriev, M. V.

doi:10.7868/S3034559625030057

RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

ISSN (Print) 0044-460X

ISSN (Online) 3034-5596

Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones

PII

S30345596S0044460X25030057-1

DOI

10.7868/S3034559625030057

Publication type

Article

Status

Published

Authors

K.V. Podchezertseva

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

N. A. Buzmakova

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

T. M. Zamaraeva

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

S. S. Zykova

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

M. V. Dmitriev

Affiliation: Perm State National Research University

Volume/ Edition

Volume 95 / Issue number 3-4

Pages

114-120

Abstract

4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones were obtained by the reaction of dimethyl malonate (diethyl malonate), aromatic aldehyde, and 1H-benzimidazole-2-amine in methanol (ethanol) in the presence of piperidine for 6 h. Structure of the compounds was confirmed by 1H, 13C NMR spectroscopy and X-ray diffraction analysis. Antioxidant activity of the synthesized compounds was studied.

Keywords

диалкилмалонаты арилальдегиды 1Н-бензимидазол-2-амин пиперидин бензо[4,5]-имидазо[1,2-a]пиримидин-2(1H)-оны антиоксидантная активность

Date of publication

06.02.2026

Year of publication

2026

Number of purchasers

Views

References

GOST	Buzmakova N., Dmitriev M., Podchezertseva K., Zamaraeva T., Zykova S. Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones // Russian Journal of General Chemistry. – 2025. – V. 95. – Issue number 3-4 C. 114-120 . URL: https://genchemras.ru/s30345596s0044460x25030057-1/?version_id=123130. DOI: 10.7868/S3034559625030057
MLA	Buzmakova, N. A, Dmitriev, M. V, Podchezertseva, K.V, Zamaraeva, T. M, Zykova, S. S "Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones." Russian Journal of General Chemistry. 95.3-4 (2025).:114-120. DOI: 10.7868/S3034559625030057
APA	Buzmakova N., Dmitriev M., Podchezertseva K., Zamaraeva T., Zykova S. (2025). Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones. Russian Journal of General Chemistry. vol. 95, no. 3-4, pp.114-120 DOI: 10.7868/S3034559625030057

RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones

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Synthesis, Structure, and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones

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