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RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

  • ISSN (Print) 0044-460X
  • ISSN (Online) 3034-5596

Synthesis and Biological Activity of Bis-1,3,4-oxadiazoles (A Review)

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PII
S3034559625090019-1
DOI
10.7868/S3034559625090019
Publication type
Review
Status
Published
Authors
R.D. Rak
  • Affiliation: St. Petersburg State Institute of Technology (Technical University)
E.A. Gerasimova
  • Affiliation: St. Petersburg State Institute of Technology (Technical University)
D.M. Egorov
  • Affiliation: St. Petersburg State Institute of Technology (Technical University)
Volume/ Edition
Volume 95 / Issue number 9-10
Pages
357-370
Abstract
The review presents achievements in the field of synthesis and study of biological activity of various bis-1,3,4-oxadiazoles from 1999 to 2024. The methods for obtaining bis-1,3,4-oxadiazoles repeat the methods used to obtain 1,3,4-oxadiazoles and are mainly implemented due to intramolecular cyclization under the action of phosphorus oxychloride or bases. Oxidative cyclization reactions play a major role. Single examples of the application of the Huisgen reaction and an electrochemical version of cyclization are presented. The main direction of the study of biological activity is antibacterial, and studies of antifungal and anticancer activity are also presented.
Keywords
1,3,4-оксадиазолы гидразиды циклизация биологическая активность
Date of publication
06.02.2026
Year of publication
2026
Number of purchasers
0
Views
132

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