- PII
- S0044460X25010022-1
- DOI
- 10.31857/S0044460X25010022
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 95 / Issue number 1-2
- Pages
- 10-16
- Abstract
- A one-pot four-component solvent-free reaction of N-methyl acetoacetamide with dimedone, aromatic aldehyde and ammonium acetate leads to new substituted N-methyl 1,4,5,6,7,8-hexahydroquinoline-3-carboxamides. The structures of the products were proved using IR, 1H and 13C NMR spectroscopy. The synthesized compounds were tested for antimicrobial and antinociceptive activities. The resulting compounds have shown antinociceptive activity greater than that of metamizole sodium.
- Keywords
- N-метил-5-оксо-1,4,5,6,7,8-гексагидрохинолин-3-карбоксамиды N-метилацетоацетамид димедон антиноцицептивная активность
- Date of publication
- 17.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 27
References
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