- PII
- 10.31857/S0044460X24080051-1
- DOI
- 10.31857/S0044460X24080051
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 94 / Issue number 8
- Pages
- 913-928
- Abstract
- Low molecular mono- and diamines (3-aminopropyltriethoxysilane, hexamethylenediamine, 1,4-diaminobutane), and high molecular weight polydimethylsiloxane with terminal amine groups were studied as catalysts in the synthesis of cross-linked composite films based on polydimethylsiloxane with terminal hydroxyl groups, tetraethoxysilane a cross-linking agent and containing sodium diclofenac as a physiologically active compound. Polyethylene glycol PEG200 was used as a hydrophilizing component for the hydrophobic silicone matrix. The chemical structure of amine catalysts and polyethylene glycol presence have significant effect on structure and properties of the composites, thereby determining the kinetics and degree of prolonged release of diclofenac from the films.
- Keywords
- полидиметилсилоксан аминные катализаторы полиэтиленгликоль композиционные пленки диклофенак натрия
- Date of publication
- 17.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 9
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