- PII
- 10.31857/S0044460X23090032-1
- DOI
- 10.31857/S0044460X23090032
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 93 / Issue number 9
- Pages
- 1335-1342
- Abstract
- Substituted prop-2-en-1-ones were obtained by the condensation reaction of 1-biphenyl-4-yl-ethanone with aromatic aldehydes in the presence of sodium hydroxide in an aqueous ethanol solution. Subsequent cyclization of the latter with hydrazine hydrate, phenylhydrazine, and thiosemicarbazide in an acidic medium leads to the corresponding pyrazolines. The reaction of amidine hydrochlorides with chalcones in a KOH-ethanol system leads to 2,4,6-trisubstituted pyrimidines. The luminescent and antibacterial properties of the resulting systems was studied.
- Keywords
- замещенные проп-2-ен-1-оны люминесценсия пиразолины пиримидины гетероциклизация антибактериальная активность
- Date of publication
- 15.09.2023
- Year of publication
- 2023
- Number of purchasers
- 0
- Views
- 30
References
- 1. Li J.-T., Zhang X.-H., Lin Z.-P. // Beilstein J. Org. Chem. 2007. Vol. 3. N 13. doi 10.1186/1860-5397-3-13
- 2. Li Q.S., Shen B.N., Zhang Z., Luo S., Ruan B.F. // Curr. Med. Chem. 2021. Vol. 28. N 5. P. 940. doi 10.2174/0929867327666200306120151
- 3. Patil S.B. // Int. J. Pharm. Sci. Res. 2018. Vol. 9. N 1. P. 44. doi 10.13040/IJPSR.0975-8232.9(1).44-52
- 4. Elkanzi N.A.A. // Orient. J. Chem. 2020. Vol. 36. N 6. P. 1001. doi 10.13005/ojc/360602
- 5. Sviripa V.M., Zhang W., Balia A.G., Tsodikov O.V., Nickell J.R., Gizard F., Yu T., Lee E.Y., Dwoskin L.P., Watt D.S. // J. Med. Chem. 2014. Vol. 57. P. 6083. doi 10.1021/jm5004864
- 6. Varghese B., Al-Busafi S.N., Suliman F.O., AlKindy S.M.Z. // RSC Adv. 2017. Vol. 7. P. 46999. doi 10.1039/C7RA08939B
- 7. Selivanova D.G., Gorbunov A.A., Mayorova O.A., Vasyanin A.N., Lunegov I.V., Shklyaeva E.V., Abashev G.G. // Beilstein J. Org. Chem. 2017. Vol. 13. P. 1583. doi 10.3762/bjoc.13.158.
- 8. Achelle S., Rodríguez-Lopez J., Larbani M., Plaza-Pedroche R., Robin-le Guen F. // Molecules. 2019. Vol. 24. P. 1742. doi 10.3390/molecules24091742
- 9. Shivananda M.K., Holla B.S. // J. Chem. Pharm. Res. 2017. Vol. 9. N 6. P. 1.
- 10. Руководство по проведению доклинических исследований лекарственных средств / Под ред. А.Н. Миронова. М.: Медицина, 2012. С. 509.
- 11. Машковский М.Д. Лекарственные средства. М.: Новая волна, 2010. С. 851.
