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RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

  • ISSN (Print) 0044-460X
  • ISSN (Online) 3034-5596

Copper(II) сomplexes with 2-hydrохy-5-ethylphenylphosphosphonic acid: synthesis, structure, cytotoxicity, and accumulation in HeLa cells

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PII
10.31857/S0044460X23060161-1
DOI
10.31857/S0044460X23060161
Publication type
Article
Status
Published
Authors
M. V. Kozlova
  • Affiliation: Institute of Physiologically Active Substances of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences
V. E Baulin
  • Affiliation: Institute of Physiologically Active Substances of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences
Volume/ Edition
Volume 93 / Issue number 6
Pages
967-977
Abstract
In order to study the physicochemical and biological properties of the coordination compounds of bioactive metal ions with 2-hydroxyphenylphosphonic acid derivatives, the reaction of 2-hydroxy-5-ethylphenylphosphonic acid (Н3L1) with copper(II) perchlorate, sulfate, nitrate, and acetate in water was studied for the first time. It has been established that, regardless of the ratio of reagents, in the case of copper(II) perchlorate, sulfate, and nitrate, a complex of the composition [Cu(H2L1)2(Н2О)2] is formed in high yield, while in the case of using copper(II) acetate a complex [Cu(HL1)(H2O)2] is formed, the composition of which is established on the basis of a combination of elemental analysis data, IR and electronic spectra. Quantum-chemical calculations of the structure of [Cu(H2L1)2(H2O)2] and [Cu(HL1)(H2O)2] complexes were performed for the first time by the density functional theory (DFT) method. The cytotoxic properties of H3L1 acid and copper complexes [Cu(HL1)(H2O)2] and [Cu(H2L1)2(H2O)2] with respect to HeLa tumor cells of human cervical adenocarcinoma were studied. The accumulation of the resulting copper(II) complexes in HeLa cells was proved by laser confocal microscopy.
Keywords
2-гидроксифенил-5-этилфосфоновая кислота комплексы меди(II) клетки HeLa токсичность лазерная конфокальная микроскопия
Date of publication
17.09.2025
Year of publication
2025
Number of purchasers
0
Views
14

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