- PII
- 10.31857/S0044460X23050049-1
- DOI
- 10.31857/S0044460X23050049
- Publication type
- Article
- Status
- Published
- Authors
- Volume/ Edition
- Volume 93 / Issue number 5
- Pages
- 684-694
- Abstract
- A reproducible and scalable method for the synthesis was developed, and a series of 3,6-substituted pyrazolo[1,5- a ]pyrimidines, which are the basis for the rational design of selective inhibitors of AMP-activated protein kinase, was obtained and characterized. In the course of the formation of new types of carbon skeleton, the possibility of applying Suzuki-Miyaura cross-coupling with Buchwald ligands to form C-C bond in the sterically hindered position 6 of 5,7-dimethyl-substituted pyrazolo[1,5- a ]pyrimidine was shown.
- Keywords
- пиразоло[1,5-a]пиримидин пиридин-1H-пиразол-5-амин ингибитор АМФК кросс-сочетание
- Date of publication
- 17.09.2025
- Year of publication
- 2025
- Number of purchasers
- 0
- Views
- 16
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