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RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

  • ISSN (Print) 0044-460X
  • ISSN (Online) 3034-5596

Biocompatible microemulsions based on oleic acid modified with piperidinium surfactants

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PII
10.31857/S0044460X23030162-1
DOI
10.31857/S0044460X23030162
Publication type
Article
Status
Published
Authors
A. B Mirgorodskaya
  • Affiliation: Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
M. V. Kozlova
  • Affiliation: Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
Volume/ Edition
Volume 93 / Issue number 3
Pages
483-492
Abstract
A number of microemulsions based on oleic acid and Tween 80, modified with piperidinium surfactants, have been obtained and characterized. The effect of additives on the size, stability, and solubilization effect of the formed systems with respect to hydrophilic (rhodamine B) and hydrophobic (indomethacin) substances was studied. By varying the ratio of components, it was possible to form microemulsions that differ greatly in viscosity: from easy-flowing compositions to gels. The kinetic parameters describing release process of substrates from microemulsions have been obtained. In vivo tests of the anti-inflammatory action of microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug. In vivo tests of the anti-inflammatory action of microemulsions loaded with indomethacin have shown that the presence of piperidinium surfactants enhances the therapeutic effect of the drug.
Keywords
микроэмульсия пиперидиниевые ПАВ вязкость размер противовоспалительное действие
Date of publication
17.09.2025
Year of publication
2025
Number of purchasers
0
Views
13

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