Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides

Zvereva, O. V.; Limansky, E. S.; Chashchina, S. V.; Chernov, I. N.; Mokrushin, I. G.; Igidov, N. M.

doi:10.7868/S3034559625030021

RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

ISSN (Print) 0044-460X

ISSN (Online) 3034-5596

Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides

PII

S30345596S0044460X25030021-1

DOI

10.7868/S3034559625030021

Publication type

Article

Status

Published

Authors

O. V. Zvereva

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

E. S. Limansky

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

S. V. Chashchina

Affiliation:
Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation
Perm State National Research University

I. N. Chernov

Affiliation: National Research Nizhny Novgorod State University named after N. I. Lobachevsky

I. G. Mokrushin

Affiliation: Perm State National Research University

N. M. Igidov

Affiliation: Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Volume/ Edition

Volume 95 / Issue number 3-4

Pages

92-98

Abstract

A series of new N-alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides were obtained by decyclization of 4-arylamino-2-tert-butyl-2,5-dihydro-5-oxofuran-2-yl acetates under the action of aliphatic amines. The analgesic activity of the synthesized compounds was studied.

Keywords

4-ариламино-2-трет-бутил-2,5-дигидро-5-оксофуран-2-илацетаты бензиламин фенетиламин N-алкил-2-ариламино-5,5-диметил-4-оксогекс-2-енамиды анальгетическая активность

Date of publication

06.02.2026

Year of publication

2026

Number of purchasers

Views

References

GOST	Chashchina S., Chernov I., Igidov N., Limansky E., Mokrushin I., Zvereva O. Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides // Russian Journal of General Chemistry. – 2025. – V. 95. – Issue number 3-4 C. 92-98 . URL: https://genchemras.ru/s30345596s0044460x25030021-1/?version_id=123127. DOI: 10.7868/S3034559625030021
MLA	Chashchina, S. V, Chernov, I. N, Igidov, N. M, Limansky, E. S, Mokrushin, I. G, Zvereva, O. V "Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides." Russian Journal of General Chemistry. 95.3-4 (2025).:92-98. DOI: 10.7868/S3034559625030021
APA	Chashchina S., Chernov I., Igidov N., Limansky E., Mokrushin I., Zvereva O. (2025). Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides. Russian Journal of General Chemistry. vol. 95, no. 3-4, pp.92-98 DOI: 10.7868/S3034559625030021

RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides

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