Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry

Kozlova, M. V.; Gerasimov, A. V

doi:10.31857/S0044460X23050141

PII

10.31857/S0044460X23050141-1

DOI

10.31857/S0044460X23050141

Publication type

Article

Status

Published

Authors

M. V. Kozlova

Affiliation: A.M. Butlerov Institute of Chemistry, Kazan (Volga Region) Federal University

A. V Gerasimov

Affiliation: A.M. Butlerov Institute of Chemistry, Kazan (Volga Region) Federal University

Volume/ Edition

Volume 93 / Issue number 5

Pages

794-800

Abstract

In the present work, an amorphous active pharmaceutical ingredient, phenacetin, was obtained by fast scanning calorimetry. The critical cooling rate and kinetic fragility of its supercooled melt were determined. The process of cold crystallization of phenacetin was studied by methods of isothermal and non-isothermal kinetics. It was found that the best correspondence between the two kinetic approaches is observed in the case of using the Nakamura crystallization model. The results obtained can find their application in the development of approaches to obtaining amorphous forms of drugs prone to crystallization.

Keywords

активный фармацевтический ингредиент стеклообразующая способность кинетика кристаллизации сверхбыстрая калориметрия

Date of publication

17.09.2025

Year of publication

2025

Number of purchasers

Views

References

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GOST	Gerasimov A., Kozlova M. Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry // Russian Journal of General Chemistry. – 2023. – V. 93. – Issue number 5 C. 794-800 . URL: https://genchemras.ru/10-31857-s0044460x23050141-1/?version_id=113204. DOI: 10.31857/S0044460X23050141
MLA	Gerasimov, A. V, Kozlova, M. V "Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry." Russian Journal of General Chemistry. 93.5 (2023).:794-800. DOI: 10.31857/S0044460X23050141
APA	Gerasimov A., Kozlova M. (2023). Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry. Russian Journal of General Chemistry. vol. 93, no. 5, pp.794-800 DOI: 10.31857/S0044460X23050141

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Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry

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RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry

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