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RAS Chemistry & Material ScienceЖурнал общей химии Russian Journal of General Chemistry

  • ISSN (Print) 0044-460X
  • ISSN (Online) 3034-5596

Synthesis, anticholinesterase and anti-radical activity of 2,3,5-trisubstituted 4H-imidazol-4-ones, green fluorescent protein chromophore analogues

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PII
10.31857/S0044460X23040017-1
DOI
10.31857/S0044460X23040017
Publication type
Article
Status
Published
Authors
A. T Makichyan
  • Affiliation:
    Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia
    Russian-Armenian University
M. V. Kozlova
  • Affiliation: Scientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of the Republic of Armenia
Volume/ Edition
Volume 93 / Issue number 4
Pages
495-506
Abstract
The one-pot synthesis of N -substituted α,β-dehydrotyrosyl dipeptides was carried out by the azlactone method. The target dipeptides were obtained in good yields (53-79%). From the latter, 2,3,5-trisubstituted 4-imidazolones were obtained using 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. It was found that in the case of β-alanine-containing peptides, abstraction of the methyl ester of acrylic acid and the formation of 2,5-disubstituted 4-imidazoline were observed. Antiradical and anticholinesterase properties of the synthesized compounds were studied. Docking analysis was carried out for both some dipeptides and imidazole-4-ones.
Keywords
α,β-дегидропептиды 4(Н)-имидазол-4-оны гексаметилдисилазан антирадикальные свойства антихолинэстеразные свойства
Date of publication
15.04.2023
Year of publication
2023
Number of purchasers
0
Views
37

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